胡开顺，副研究员，硕士生导师。从事蛋白翻译后修饰在维持基因组稳定性的分子机制及其在肿瘤分子靶向治疗中的功能研究。到目前为止以第一或者通讯作者的身份发表SCI收录论文15篇，包括Journal of Clinical Investigation，Advanced Science，EMBO Reports，Oncogene，Theranostics，Signal Transduction and Targeted Therapy等高水平专业杂志。本人研究受到了5项省部级以上相关基金资助，包括2项国家自然科学基金。目前主要兴趣点在利用串联亲和纯化技术及高分辨质谱检测技术去系统鉴定参与DNA损伤应答、DNA复制及有丝分裂等生命活动中新的调控蛋白与重要蛋白新的修饰类型，同时进一步深入阐明这些蛋白及其修饰类型在维持肿瘤基因组稳定性的功能、机制及临床意义。

联系方式： huksh3@mail.sysu.edu.cn

代表性文章：

(1) Hu, Kaishun^#; Li, Yu^#; Wu, Wenjing^#; Xie, Limin^#; Yan, Haiyan; Cai,

Yuexin; Chen, Dong; Jiang, Qiongchao; Lin, Lehang; Chen, Zhen; Liao, Jian-You;Zhang, Yin; Koeffler, H Phillip; Yin, Dong^*; Song, Erwei^*; ATM-DependentRecruitment of BRD7 is required for Transcriptional Repression and DNA Repairat DNA Breaks Flanking Transcriptional Active Regions., Adv Sci (Weinh), 2020,7(20): 0-2000157.

(2) Hu, Kaishun^#; Wu, Wenjing^#; Li, Yu^#; Lin, Lehang; Chen, Dong; Yan,

Haiyan; Xiao, Xing; Chen, Hengxing; Chen, Zhen; Zhang, Yin; Xu, Shuangbing;

Guo, Yabin; Koeffler, H Phillip; Song, Erwei^*; Yin, Dong^*; Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents, EMBO Reports, 2019, 20(5): 0-e46166.

(3) Yang, Yang^#; Ma, Yuedong^#; Gao, Huabin^#; Peng, Tingsheng; Shi, Huijuan;

Tang, Yunxiang; Li, Hui; Chen, Lin; Hu, Kaishun^*(并列通讯作者); Han, Anjia^*; A novelHDGF-ALCAM axis promotes the metastasis of Ewing sarcoma via regulating theGTPases signaling pathway, Oncogene, 2020, 40(4): 731-745.

(4) Zhou, Liwen^#; Zheng, Lisi^#; Hu, Kaishun^#(并列第一作者); Wang, Xin; Zhang, Ruhua; Zou,Yezi; Zhong, Li; Wang, Shang; Wu, Yuanzhong^*; Kang, Tiebang^*; SUMOylationstabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites, Signal Transduction and Targeted Therapy, 2020, 5(1): 0-80.

(5) Chen, Hengxing^#; Li, Yun^#; Li, Yu; Chen, Zhen; Xie, Limin; Li, Wenjia;

Zhu, Yuanxin; Xue, Hong; Koeffler, H Phillip; Wu, Wenjing; Hu, Kaishun^*(并列通讯作者); Yin,Dong^*; PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubuledrugs chemosensitivity via degradation of phospho-BCL-2, Theranostics, 2020, 10(22): 9984-10000.

(6) Hu K^#, Li Y^#, Wu W^#, Chen H, Chen Z, Zhang Y, Guo Y^*, Yin D^*, High-performance gene expression and knockout tools using sleeping beauty transposon system, Mob DNA. 2018 Nov 26; 9:33.

(7) Huang Y^#,Hu K^#(并列第一作者), Zhang S^#, Dong X, Yin Z, Meng R, Zhao Y, Dai X, Zhang T, Yang K, Liu L, Huang K, Shi S, Zhang Y, Chen J, Wu G^*, Xu S^*, S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. Theranostics. 2018 Feb 2;8(5):1286-1300.

(8) Hong J^#, Hu K^#(并列第一作者), Yuan Y^*, Sang Y, Bu Q, Chen G, Yang L, Li B, Huang P, Chen D, Liang Y, Zhang R, Pan J, Zeng YX, Kang T^*. CHK1 Targets Spleen Tyrosine Kinase (L) for Proteolysis in Hepatocellular Carcinoma，J Clin Invest. 2012 Jun;122(6):2165-75.  

主持科研项目：

(1)国家自然科学基金委员会，面上项目，81772821, 半胱氨酸富含蛋白CCN1调控同源重组修复的分子机制及在乳腺癌放化疗中的功能研究, 2018-01至2021-12，52万元，在研，主持；

(2)国家自然科学基金委员会，青年项目，81301732, BRD7与细胞周期蛋白CDC5L相互作用的机制及其在结直肠癌中的意义, 2014-01至2016-12，23万元，已结题，主持；