FACULTY

Liu Qiang

2012-12-18 00:29
M.D. & Ph.D.
Professor of Surgery
Doctoral Supervisor
Deputy Director of Breast Tumor Center, SYSH
Director of International Office, SYSH

Clinical Focus
Diagnosis and Treatment of Benign Breast Diseases, Diagnosis and Treatment of Malignant Breast Diseases, Individualized Breast Cancer Treatment, Early Diagnosis and Treatment of Breast Cancer



Research Interest
Prof. Liu Qiang has been working on the frontline of breast cancer treatment and clinical research of breast diseases for years. Carrying out in-depth studies on breast cancer pathogenesis, Prof. Liu Qiang are expert at the early diagnosis and individualized treatment of breast cancer. His studies on the Relationship Between Tamoxifen and the Target Cells of Cyclin D1-C/EBPβ Signaling Pathway in Human Breast Carcinogenesis has won national grants from National Natural Science Foundation. Prof. Liu Qiang has also joined the Harvard/MIT Breast Cancer Collaborative Group and worked closely with world-renown experts in breast cancer research such as Robert Weinberg, who has discovered HER2 Gene, and David Livingston, who leads the research on BRCA1 and BRCA2. Prof. Liu Qiang’s research on Cyclin D1 function in tumorigenesis and differentiation has earned the support from National Institutes of Health.



Academic Achievement
Prof. Liu Qiang was recruited back to China from the U.S through the Hundred Talent Recruitment Program of Sun Yat-Sen University in 2011. He has published 18 SCI papers on Carcinogenesis, Cancer Research and Cancer Cell, and is the co-author of two English profession books on Breast Cancer Research. Prof. Liu Qiang is a frequent guest and presenter at international symposiums. He has won Full Scholarships for Surgical PHD Students at the National University of Singapore from January 2000 to January 2004. At the same year, he was granted Mrs Ivy Wu Fellowship for Surgery from the Faculty of Medicine at the University of Hong Kong, which he chose to give up for the full scholarship at the National University of Singapore.



Education/ Training
1989-1994,  Bachelor of Medicine (equivalent to M.D. in US), Xiang Ya School of Medicine, Central South University, China

1994-1996,  Master of Surgery, Xiang Ya School of Medicine, Central South University, China

2000~2004,  Ph.D., Dept. of Surgery, Yong Loo Lin School of Medicine, National University of Singapore

2004~2008,  Postdoc Research Fellow, Cancer Research Institute of National University of Singapore

2004~2008,   Postdoc Research Fellow, Dana-Farber/Harvard Cancer Center

2008~2011,  Instructor in Medicine, Dana-Farber/Harvard Cancer Center and Oncology Department of Brigham and Women Hospital



Social Responsibility
Active member, American Association for Cancer Research
Lifelong member, Chinese Medical Association
Reviewer of GUT
Reviewer of Molecular and Cellular Biology
Reviewer of National Natural Science Foundation of China

 

Representative Publications
1. Liu Q, Boudot A, Ni J, Hennessey T, Beauparlant S, Rajabi H, Zahnow CA, Ewen ME. Cyclin D1 and C/EBPβ LAP1 operate in a common pathway to promote mammary epithelial cell differentiation. Mol Cell Biol. In press.

2. Tang W, Yu F, Yao H, Cui X, Jiao Y, Lin L, Chen J, Yin D, Song E#, Liu Q#. miR-27a regulates endothelial differentiation of breast cancer stem like cells. Oncogene. 2014, 33(20):2629-38. (# co-corresponding author)

3. Su S*, Liu Q*, Chen J, Chen J, Chen F, He C, Wu W, Lin L,Li H, Huang D, Huang W, Yu F, Zhang J, Cui X, Zheng F, Yao H, Su F, Song E. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell. 2014, 25(5):605-620 (*, co-first author)

4. Li S, Liu J, Yang Y, Zeng Y, Deng H, Jia H, Li Q, Feng H, Li Y, Song E, Liu Q#, Su F#. Impact of atypical hyperplasia at margins of breast-conserving surgery on the recurrence of breast cancer. J Cancer Res Clin Oncol. 2014, 140(4):599-605 (# co-corresponding author)

5. Li HY, Cui XY, Wu W, Yu FY, Yao HR, Liu Q, Chen JQ. Pyk2 and Src mediate signaling to CCL18-induced breast cancer metastasis. J Cell Biochem. 2014, 115:596-603.

6. Liu Y, Li H, Feng J, Cui X, Huang W, Li Y, Su F, Liu Q, Zhu J, Lv X, Chen J, Huang D, Yu F. Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells. PLoS One. 2013, 8(12):e83083.

7. Gong C, Qu S, Liu B, Pan S, Jiao Y, Nie Y, Su F, Liu Q#, Song E#. MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells. Oncogene, 2013 Dec 2. doi: 10.1038/onc.2013.525. (# co-corresponding author)

8. Tang W, Zhu J, Su S, Wu W, Liu Q, Su F, Yu F. MiR-27 as a prognostic marker for breast cancer progression and patient survival. PLoS One. 2012;7(12):e51702.

9. Yao YD, Sun TM, Huang SY, Dou S, Lin L, Chen JN, Ruan JB, Mao CQ, Yu FY, Zeng MS, Zang JY, Liu Q, Su FX, Zhang P, Lieberman J, Wang J, Song E. Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis. Sci Transl Med. 2012 Apr 18;4(130):130ra48..

10. Sun L, Yao Y, Liu B, Lin Z, Lin L, Yang M, Zhang W, Chen W, Pan C, Liu Q, Song E, Li J. MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene 2012, 31(4):432-445. 

11. Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Su F, Anderson KS, Liu Q, Ewen ME, Yao X, Song E. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 2011, 19(4):541-555.

12. Gong C, Yao H, Liu Q, Chen J, Shi J, Su F, Song E. Markers of tumor-initiating cells predict chemoresistance in breast cancer. PLoS One. 2010 Dec 20;5(12):e15630

13. Yu F, Deng H, Yao H, Liu Q, Su F, Song E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene. 2010, 29(29):4194-4204

14. Chang TL, Ito K, Ko TK, Liu Q, Salto-Tellez M, Yeoh KG, Ito Y. Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. Gastroenterology. 2010, 138(1):255-265

15. Müller CI, Luong QT, Shih LY, Jones LC, Desmond JC, Kawamata N, Tcherniantchouk O, Liu Q, Ito K, Osato M, Ito Y, Tefferi A, de Vos S, Koeffler HP. Identification of marker genes including RUNX3 (AML2) that discriminate between different myeloproliferative neoplasms and normal individuals. Leukemia. 2008, 22(9):1773-1778

16. Liu Q, Inoue H, Mahendran R. Transcriptional regulation of the COX-2 expression by nitric oxide in colon cancer cell lines. Oncol Rep. 2008, 19(1):269-274

17. Liu Q, Teh M, Ito K, Shah N, Ito Y, Yeoh KG. CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. Mod Pathol, 2007, 20(12):1286-1297

18. Lau QC, Raja E, Salto-Tellez M, Liu Q, Ito K, Inoue M, Putti TC, Loh M, Ko TK, Huang C, Ito Y, Sukumar S. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Research, 2006, 66(13):6512-6520

19. Ito K, Liu Q, Salto-Tellez M, Yano T, Tada K, Ida H, Huang C, Shah N, Inoue M, Rajnakova A, Hiong KC, Peh BK, Han HC, Ito T, Teh M, Yeoh KG, Ito Y. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Research, 2005, 65(17): 7743-7750

20. Liu Q, Chan STF, Mahendran R. Nitric Oxide induces cyclooxygenase expression and inhibits cell growth in colon cancer cell lines. Carcinogenesis, 2003, 24(4): 637-642

21. Liu PX, Liu Q, Lv XS, Wu SB, Tang H. Effects of ischemic preconditioning and triiodothyronine on small intestinal ischemia/reperfusion injury. Chinese Journal of Digestion, 1999,19(3): 179-181

22. Liu PX, Wu SB, Liu Q, Lv XS, Tang H. Influence of triiodothyronine and insulin on liver adenine nucleotide levels in portal triad-clamping rats. Bulletin of Hunan Medical University, 1999, 24(2): 113-115

23. Liu PX, Liu Q, Lv XS, Wu SB, Tang H. Effects of ischemic preconditioning on small intestinal ischemia/reperfusion injury. Chinese Journal of Experimental Surgery, 1998, 15 (5): 447-448

24. Liu PX, Wu SB, Lv XS, Liu Q, Tang H. Effects of ischemic preconditioning on warm ischemia/reperfusion injury of rat liver Chinese Journal of Experimental Surgery, 1998, 15 sup: 1-2

 

ContactUs

Contact Number
0086-020-81332199
Working Time
am 08:00-12:00
pm 14:30-17:30
Address
107 Yan Jiang West Road
Guangzhou
P.R. China
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